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In a controlled study, variation in ischemia/reperfusion tolerance across time of day has been previously explored, showing an increase in infarct volume and fibrosis at the onset of activity (ZT12) compared to the beginning of the inactive period (ZT0) in WT mice (Durgan et al., 2010)

Proteomic analysis of the antidepressant effects of Shen-Zhi-Ling in depressed patients: identification of proteins associated with platelet activation and lipid metabolism